{
  "source": {
    "PMID": "35024243",
    "DOI": "10.1016/j.omtn.2021.12.003",
    "model": "Neuro-2a mouse cells",
    "screen_exposure": "5 uM, 5 h; not a treatment recommendation"
  },
  "n_drugs": 704,
  "n_controls": 1,
  "S1_n_rows": 704,
  "published_q_both_le_0_05_drugs": [
    "Montelukast sodium",
    "Diphenylcyclopropenone",
    "Cladribine",
    "Hexachlorophene",
    "Artesunate",
    "Topotecan hydrochloride",
    "Albendazole",
    "Homoharringtonine"
  ],
  "published_q_both_le_0_01_drugs": [
    "Topotecan hydrochloride",
    "Homoharringtonine"
  ],
  "Fisher_recompute_max_abs_error": 7e-06,
  "BH_max_abs_error": {
    "FDR_Fisher": 6.025e-05,
    "FDR_permutation": 5.000000000143778e-07
  },
  "z_model_max_abs_errors": {
    "include_control=True,ddof=0": 0.000172184848743262,
    "include_control=True,ddof=1": 5.001147351246793e-07,
    "include_control=False,ddof=0": 0.017383593027620964,
    "include_control=False,ddof=1": 0.017212342717991186
  },
  "Fisher_from_reconstructed_z_max_abs_error": 4.99386491159548e-07,
  "Fisher_q_from_reconstructed_z_max_abs_error": 4.6903227768346767e-07,
  "ratio_audit": {
    "n_rows": 2113,
    "n_reversed_bounds": 1016,
    "n_low_matches_same_side_division": 2113,
    "n_high_matches_same_side_division": 2113,
    "max_ratio_error": 0.0,
    "n_SEM_formulas_using_central_and_bounds": 2113
  },
  "descriptive_threshold_sensitivity": {
    "1": {
      "all_three_ratios_ge_threshold": 109,
      "also_both_published_q_le_0_05": [
        "Montelukast sodium",
        "Diphenylcyclopropenone",
        "Cladribine",
        "Artesunate",
        "Albendazole",
        "Homoharringtonine"
      ],
      "also_nonNMD_within_0_5_to_2": [
        "Diphenylcyclopropenone",
        "Cladribine",
        "Artesunate",
        "Albendazole",
        "Homoharringtonine"
      ]
    },
    "1.5": {
      "all_three_ratios_ge_threshold": 4,
      "also_both_published_q_le_0_05": [
        "Cladribine",
        "Albendazole",
        "Homoharringtonine"
      ],
      "also_nonNMD_within_0_5_to_2": [
        "Cladribine",
        "Albendazole",
        "Homoharringtonine"
      ]
    },
    "2": {
      "all_three_ratios_ge_threshold": 1,
      "also_both_published_q_le_0_05": [
        "Homoharringtonine"
      ],
      "also_nonNMD_within_0_5_to_2": [
        "Homoharringtonine"
      ]
    }
  },
  "screen_log2_ratio_correlation": {
    "Ptbp2_log2_ratio": {
      "Ptbp2_log2_ratio": 1.0,
      "Hnrnpl_log2_ratio": 0.25417958571668553,
      "Tra2b_log2_ratio": 0.2835198001541288
    },
    "Hnrnpl_log2_ratio": {
      "Ptbp2_log2_ratio": 0.25417958571668553,
      "Hnrnpl_log2_ratio": 1.0,
      "Tra2b_log2_ratio": 0.35255534411814804
    },
    "Tra2b_log2_ratio": {
      "Ptbp2_log2_ratio": 0.2835198001541288,
      "Hnrnpl_log2_ratio": 0.35255534411814804,
      "Tra2b_log2_ratio": 1.0
    }
  },
  "limitations": [
    "Table S2 provides normalized RQ summaries and marginal intervals, not individual Ct replicates.",
    "No BUB1B measurement or exact-genotype rescue.",
    "AS-NMD ratios do not isolate decay from alternative splicing and differential isoform regulation.",
    "Published permutation p values are reused; the stochastic permutation algorithm is not independently reproduced.",
    "Zero published permutation p values are finite-sampling outputs, not zero biological uncertainty.",
    "LOO analysis and effect thresholds are exploratory; they do not yield clinical rescue probabilities."
  ],
  "software": {
    "python": "3.12.3",
    "pandas": "2.2.3",
    "numpy": "2.3.5",
    "scipy": "1.17.0",
    "openpyxl_read_only": "3.1.5"
  },
  "inputs": [
    {
      "file": "inputs/table_S1.xlsx",
      "bytes": 62404,
      "sha256": "14c3c7c3c7344c365285eec39a53fd93d4a333eec83bbbbdab7eaa4348dcaf69"
    },
    {
      "file": "inputs/table_S2.xlsx",
      "bytes": 497402,
      "sha256": "f7107fa8e401cc6d1d2adbb68adca5baefe63472cfaf2f178e667d678c3b0007"
    },
    {
      "file": "inputs/table_S4.xlsx",
      "bytes": 116602,
      "sha256": "613713a81e0944d28e1b01f07a6e144ff286726d8686778efca6b1294f749e9b"
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  ]
}