{
  "analysis_id": "L737_RT_CONTEXT_GATE_2026-10-09",
  "source_workbook_sha256": "83b4661d839e7450abb3a4266a0dc7e94260fd100f9a6efcc6e2bd77683a5b64",
  "exact_measured_6nt_context_matches": 0,
  "nearest_measured_context_hamming_distance": 1,
  "nearest_measured_context_count": 12,
  "nearest_context_gentamicin_percent": {
    "n_numeric": 12,
    "n_right_censored": 0,
    "min": 0.175,
    "q1": 0.189,
    "median": 0.1985,
    "q3": 0.212,
    "max": 0.249
  },
  "nearest_context_untreated_percent": {
    "n_numeric": 12,
    "n_right_censored": 0,
    "min": 0.15,
    "q1": 0.16475,
    "median": 0.1745,
    "q3": 0.1835,
    "max": 0.189
  },
  "nearest_context_paired_delta_percentage_points": {
    "n_numeric": 12,
    "n_right_censored": 0,
    "min": -0.0030000000000000027,
    "q1": 0.006750000000000006,
    "median": 0.016500000000000015,
    "q3": 0.047499999999999994,
    "max": 0.099
  },
  "bub1b_variants_in_measured_table": [
    "BUB1B_R114X"
  ],
  "l737star_present_in_measured_table": false,
  "exact_coordinate_predictions_supported_models": [
    {
      "treatment": "DAP",
      "chrom": "chr15",
      "chromStart": "40209699",
      "chromEnd": "40209702",
      "predicted_readthrough_percent": "2.26162953366682",
      "model_status": "supported_six_drug_model"
    },
    {
      "treatment": "SJ6986",
      "chrom": "chr15",
      "chromStart": "40209699",
      "chromEnd": "40209702",
      "predicted_readthrough_percent": "1.83080947387714",
      "model_status": "supported_six_drug_model"
    },
    {
      "treatment": "Clitocine",
      "chrom": "chr15",
      "chromStart": "40209699",
      "chromEnd": "40209702",
      "predicted_readthrough_percent": "1.62630724928543",
      "model_status": "supported_six_drug_model"
    },
    {
      "treatment": "SRI",
      "chrom": "chr15",
      "chromStart": "40209699",
      "chromEnd": "40209702",
      "predicted_readthrough_percent": "1.62544087646",
      "model_status": "supported_six_drug_model"
    },
    {
      "treatment": "CC90009",
      "chrom": "chr15",
      "chromStart": "40209699",
      "chromEnd": "40209702",
      "predicted_readthrough_percent": "0.53663527957125",
      "model_status": "supported_six_drug_model"
    },
    {
      "treatment": "G418",
      "chrom": "chr15",
      "chromStart": "40209699",
      "chromEnd": "40209702",
      "predicted_readthrough_percent": "0.451624477360517",
      "model_status": "supported_six_drug_model"
    }
  ],
  "exact_coordinate_predictions_excluded_low_signal_models": [
    {
      "treatment": "FUr",
      "chrom": "chr15",
      "chromStart": "40209699",
      "chromEnd": "40209702",
      "predicted_readthrough_percent": "0.340130388659799",
      "model_status": "excluded_low_signal_model"
    },
    {
      "treatment": "Gentamicin",
      "chrom": "chr15",
      "chromStart": "40209699",
      "chromEnd": "40209702",
      "predicted_readthrough_percent": "0.0714563049975758",
      "model_status": "excluded_low_signal_model"
    }
  ],
  "decision": {
    "gentamicin_plus_mefloquine": "retain_as_low-priority_experimental_branch_only",
    "reason": [
      "No exact BUB1B L737* measurement was found in the 5,837-PTC experimental table.",
      "No exact six-nucleotide flanking-context match was present in that table.",
      "Nearest measured contexts showed only a small median gentamicin-minus-untreated increment.",
      "The gentamicin predictive model was excluded from the paper's six supported models because of low signal.",
      "Mefloquine combination evidence comes from other genes and does not model endogenous BUB1B NMD or BUBR1 function."
    ],
    "nonapproved_positive_controls": [
      "DAP",
      "SJ6986",
      "Clitocine",
      "SRI"
    ],
    "clinical_claim": "none"
  }
}