/* MVA · BUB1B case page — page-level layout on top of biolab.css tokens.
 * Scoped to .mva-research-body; charts/register live in mva-results.css and the
 * explorer, atlas and viewers in mva-mechanism.css. */
.mva-research-body .mva-page{display:block}
.mva-section-number{display:block;color:var(--bl-blue-deep);font-size:.8rem;font-weight:700;letter-spacing:.06em;text-transform:uppercase;margin-bottom:14px}
.mva-research-body .bl-section{padding:68px 0}
.mva-research-body .bl-section+.bl-section{border-top:1px solid var(--bl-line)}

/* Hero */
.mva-hero{padding:28px 0 56px;background:radial-gradient(55% 70% at 85% 10%,#dbe9fa 0,rgba(244,248,252,0) 70%),radial-gradient(45% 55% at 5% 95%,#ece7fb 0,rgba(244,248,252,0) 70%),var(--bl-bg)}
.mva-hero-grid{display:grid;grid-template-columns:minmax(0,1.25fr) minmax(300px,.85fr);gap:48px;align-items:start}
.mva-hero h1{font-size:clamp(2.4rem,4.4vw,3.6rem);letter-spacing:-.035em}
.mva-hero-subtitle{margin-top:10px;font-size:1.2rem;font-weight:500;color:var(--bl-text-soft)}
.mva-hero-lead{margin-top:20px;font-size:1.05rem;line-height:1.7;color:var(--bl-text-soft);max-width:620px}
.mva-hero-boundary{margin-top:24px;max-width:640px}
.mva-hero .bl-actions{margin-top:26px}
.mva-facts{padding:26px 28px}
.mva-facts h2{font-size:.82rem;font-weight:700;letter-spacing:.06em;text-transform:uppercase;color:var(--bl-blue-deep)}
.mva-facts dl{margin:18px 0 0;display:grid;gap:16px}
.mva-facts dl>div{display:grid;gap:5px;padding-top:16px;border-top:1px solid var(--bl-line)}
.mva-facts dt{font-size:.78rem;font-weight:600;color:var(--bl-muted);text-transform:uppercase;letter-spacing:.04em}
.mva-facts dd{margin:0;font-size:.95rem;line-height:1.55;color:var(--bl-text)}
.mva-facts dd span{display:block;color:var(--bl-text-soft);font-size:.88rem;margin-top:8px}
.mva-facts dd strong{font-weight:600}
.mva-intro{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:18px;margin-top:52px}
.mva-intro article{background:#fff;border:1px solid var(--bl-line);border-radius:var(--bl-radius);padding:24px;box-shadow:var(--bl-shadow)}
.mva-intro h2{font-size:1.2rem;line-height:1.3;letter-spacing:-.02em}
.mva-intro p{margin-top:12px;color:var(--bl-text-soft);font-size:.95rem;line-height:1.65}
.mva-stats{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:14px;margin-top:18px}
.mva-stats article{display:flex;align-items:center;gap:14px;border:1px solid var(--bl-line);border-radius:var(--bl-radius-sm);padding:16px 18px;background:rgba(255,255,255,.6)}
.mva-stats strong{font-size:1.7rem;font-weight:700;letter-spacing:-.03em;color:var(--bl-blue-deep);font-variant-numeric:tabular-nums;line-height:1}
.mva-stats span{font-size:.85rem;line-height:1.4;color:var(--bl-text-soft)}

/* 01 Summary */
.mva-conclusion-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:20px}
.mva-conclusion{--tone:var(--bl-blue);display:flex;flex-direction:column;background:#fff;border:1px solid var(--bl-line);border-top:4px solid var(--tone);border-radius:var(--bl-radius);padding:24px;box-shadow:var(--bl-shadow)}
.mva-conclusion--violet{--tone:var(--bl-violet)}
.mva-conclusion--teal{--tone:var(--bl-teal)}
.mva-conclusion-label{color:var(--tone);font-size:.78rem;font-weight:700;letter-spacing:.04em;text-transform:uppercase}
.mva-conclusion h3{font-size:1.3rem;margin:12px 0 10px}
.mva-conclusion p{color:var(--bl-text-soft);font-size:.95rem;line-height:1.65}
.mva-conclusion a{display:inline-flex;align-items:center;gap:6px;margin-top:auto;padding-top:16px;font-weight:600;font-size:.92rem;text-decoration:none}
.mva-conclusion a:hover{text-decoration:underline;text-underline-offset:3px}

/* 02 Question cards */
.mva-questions{background:#fff}
.mva-question-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:22px}
.mva-question{--tone:var(--bl-blue);--tone-soft:var(--bl-blue-soft);display:flex;flex-direction:column;gap:12px;background:#fff;border:1px solid var(--bl-line);border-radius:var(--bl-radius);box-shadow:var(--bl-shadow);text-decoration:none;color:var(--bl-text);overflow:hidden;transition:transform .2s,box-shadow .25s,border-color .2s}
.mva-question:hover,.mva-question:focus-visible{transform:translateY(-3px);box-shadow:var(--bl-shadow-lg);border-color:var(--tone)}
.mva-question--violet{--tone:var(--bl-violet);--tone-soft:var(--bl-violet-soft)}
.mva-question--teal{--tone:var(--bl-teal);--tone-soft:var(--bl-teal-soft)}
.mva-question--amber{--tone:var(--bl-amber);--tone-soft:var(--bl-amber-soft)}
.mva-question-head{display:flex;align-items:center;gap:12px;padding:14px 18px;background:var(--tone-soft);color:var(--bl-text)}
.mva-question-head>.bl-icon:last-child{margin-left:auto;color:var(--bl-text-soft)}
.mva-question-icon{display:grid;place-items:center;width:38px;height:38px;border-radius:12px;background:#fff;color:var(--tone);border:1px solid rgba(20,34,59,.06)}
.mva-question-icon .bl-icon{width:20px;height:20px}
.mva-question-title{font-size:1.15rem;font-weight:700;letter-spacing:-.02em}
.mva-question-art{margin:0 18px;border-radius:var(--bl-radius-sm)}
.mva-question-caption{padding:4px 18px 0;font-weight:600;font-size:1rem;color:var(--bl-text)}
.mva-question-text{padding:0 18px 20px;color:var(--bl-text-soft);font-size:.92rem;line-height:1.6}
.mva-questions-note{margin-top:26px}

/* 05 Future validation */
.mva-next-gate{background:#fff}
.mva-next-layout{display:grid;grid-template-columns:minmax(0,1.1fr) minmax(0,.9fr);gap:32px;align-items:center}
.mva-next-steps{list-style:none;margin:0;padding:0;display:grid;gap:14px}
.mva-next-steps li{display:grid;grid-template-columns:48px minmax(0,1fr);gap:4px 16px;background:var(--bl-bg);border:1px solid var(--bl-line);border-radius:var(--bl-radius);padding:20px 22px}
.mva-next-steps li>span{grid-row:1/3;display:grid;place-items:center;width:48px;height:48px;border-radius:14px;background:#fff;border:1px solid var(--bl-line);color:var(--bl-blue-deep);font-weight:700;font-variant-numeric:tabular-nums}
.mva-next-steps h3{font-size:1.1rem}
.mva-next-steps p{color:var(--bl-text-soft);font-size:.95rem;line-height:1.6}

/* 06 Sources and limitations */
.mva-jump{display:flex;flex-wrap:wrap;gap:8px 18px;align-items:center;margin:-10px 0 22px;font-size:.9rem}
.mva-jump span{color:var(--bl-muted)}
.mva-jump a{font-weight:600;text-decoration:none}
.mva-jump a:hover{text-decoration:underline;text-underline-offset:3px}
.mva-sources-grid{display:grid;grid-template-columns:minmax(0,1fr) minmax(0,1fr);gap:20px;margin-bottom:20px;align-items:start}
.mva-scope{padding:26px}
.mva-scope h3,.mva-source-list summary span{font-size:1.1rem;font-weight:700}
.mva-scope p{margin-top:12px;color:var(--bl-text-soft);font-size:.92rem;line-height:1.7}
.mva-scope-note code{font:.8rem ui-monospace,SFMono-Regular,Menlo,monospace;background:var(--bl-bg);border:1px solid var(--bl-line);border-radius:6px;padding:1px 6px;overflow-wrap:anywhere}
.mva-source-list{padding:0;overflow:hidden}
.mva-source-list summary{list-style:none;cursor:pointer;padding:24px 26px;display:grid;gap:4px;position:relative}
.mva-source-list summary::-webkit-details-marker{display:none}
.mva-source-list summary::after{content:"+";position:absolute;right:24px;top:22px;width:32px;height:32px;display:grid;place-items:center;border-radius:50%;border:1px solid var(--bl-line-strong);color:var(--bl-blue-deep);font-weight:600}
.mva-source-list[open] summary::after{content:"−"}
.mva-source-list summary small{color:var(--bl-muted);font-size:.86rem}
.mva-source-list ol{margin:0;padding:0 26px 22px 46px;display:grid;gap:14px;border-top:1px solid var(--bl-line);padding-top:20px}
.mva-source-list li{font-size:.92rem;line-height:1.55}
.mva-source-list li a{font-weight:600;text-decoration:none}
.mva-source-list li a:hover{text-decoration:underline;text-underline-offset:3px}
.mva-source-list li small{display:block;color:var(--bl-muted);font-size:.8rem;margin-top:2px}
.mva-source-list li p{color:var(--bl-text-soft);font-size:.86rem;margin-top:4px}
.mva-track1-context{padding:0;overflow:hidden}
.mva-track1-context>summary{list-style:none;cursor:pointer;display:grid;grid-template-columns:auto minmax(0,1fr) auto;gap:8px 24px;align-items:center;padding:24px 26px}
.mva-track1-context>summary::-webkit-details-marker{display:none}
.mva-track1-context>summary .bl-kicker{margin:0}
.mva-track1-context>summary strong{font-size:1.1rem;font-weight:700}
.mva-track1-hint{color:var(--bl-blue-deep);font-weight:600;font-size:.9rem}
.mva-track1-hint::after{content:" +"}
.mva-track1-context[open] .mva-track1-hint::after{content:" −"}
.mva-track1-content{border-top:1px solid var(--bl-line);padding:8px 26px 30px}
.mva-track1-section{padding:36px 0;border-bottom:1px solid var(--bl-line)}
.mva-track1-section:last-child{border-bottom:0}
.mva-track1-section h2{font-size:1.55rem;letter-spacing:-.025em}
.mva-track1-section p{color:var(--bl-text-soft);line-height:1.7;font-size:.97rem}
.mva-split{display:grid;grid-template-columns:minmax(0,.8fr) minmax(0,1.2fr);gap:36px;align-items:start}
.mva-split>div p+p{margin-top:14px}
.mva-split-head .bl-kicker{margin-bottom:10px}
.mva-side{margin-top:14px;font-size:.9rem}
.mva-quote{margin:20px 0 0;padding:16px 20px;border-left:4px solid var(--bl-blue);background:var(--bl-blue-soft);border-radius:0 12px 12px 0;font-size:1.1rem;font-weight:500;color:var(--bl-text)}
.mva-intro-text{margin-top:14px;max-width:760px}
/* Presentation section (video facade lives in biolab.css) */
.mva-presentation-note{display:flex;align-items:flex-start;gap:8px;margin-top:18px;max-width:960px;color:var(--bl-muted);font-size:.86rem;line-height:1.5}
.mva-presentation-note .bl-icon{color:var(--bl-amber);margin-top:2px}
.mva-panel{max-width:640px;margin:26px 0;border:1px solid #27385a;border-radius:var(--bl-radius);overflow:hidden;background:#0d1b33;color:#dbe7f7;box-shadow:var(--bl-shadow)}
.mva-panel-bar{display:flex;align-items:center;gap:8px;padding:12px 16px;border-bottom:1px solid #27385a;font:.78rem ui-monospace,SFMono-Regular,Menlo,monospace}
.mva-dot{width:10px;height:10px;border-radius:50%;background:#2d4166}
.mva-panel-title{margin-left:8px;color:#dbe7f7}
.mva-panel-badge{margin-left:auto;border:1px solid #3b5584;border-radius:6px;padding:2px 8px;color:#9fc0ea;font-size:.7rem}
.mva-panel-art{aspect-ratio:640/420;overflow:hidden}
.mva-panel-art svg{display:block;width:100%;height:100%}
.mva-panel-foot{display:flex;justify-content:space-between;gap:12px;padding:10px 16px;font:.74rem ui-monospace,SFMono-Regular,Menlo,monospace;color:#9fb6d6;border-top:1px solid #27385a}
.mva-led{display:inline-block;width:7px;height:7px;border-radius:50%;background:#45bcc0;box-shadow:0 0 8px #45bcc0;margin-right:6px;vertical-align:middle}
.mva-allele-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:18px;margin-top:26px}
.mva-allele{padding:22px 24px}
.mva-allele-top{display:flex;justify-content:space-between;align-items:center;gap:12px;flex-wrap:wrap}
.mva-allele code,.mva-chips span{font:.82rem ui-monospace,SFMono-Regular,Menlo,monospace;background:var(--bl-bg);border:1px solid var(--bl-line);border-radius:6px;padding:3px 8px;color:var(--bl-text)}
.mva-allele h3{font-size:1.3rem;margin:14px 0 10px}
.mva-chips{display:flex;flex-wrap:wrap;gap:8px;margin-top:14px}
.mva-protein{margin:26px 0 0;padding:22px 24px}
.mva-protein svg{display:block;width:100%;height:auto}
.mva-protein figcaption{margin-top:12px;color:var(--bl-muted);font-size:.84rem;line-height:1.6}
.mva-p-axis text{fill:var(--bl-muted);font:12px ui-monospace,monospace}
.mva-p-label{fill:var(--bl-text);font:600 13px Inter,system-ui,sans-serif;letter-spacing:.04em}
.mva-p-body{fill:#cfe0f3}
.mva-p-lost{fill:#f1f4f8;stroke:#c4d2e3;stroke-dasharray:4 4}
.mva-p-stop{stroke:var(--bl-amber);stroke-width:3}
.mva-p-mark{fill:var(--bl-text-soft);font:600 12px Inter,system-ui,sans-serif}
.mva-p-mark--stop{fill:var(--bl-amber)}
.mva-p-note{fill:var(--bl-muted);font:12px Inter,system-ui,sans-serif}
.mva-p-domain{fill:#9c84e6}
.mva-p-domain-label{fill:#fff;font:600 12px Inter,system-ui,sans-serif}
.mva-p-hit{fill:var(--bl-amber)}
.mva-p-hit-ring{fill:none;stroke:var(--bl-amber);stroke-width:2;transform-box:fill-box;transform-origin:center;animation:mva-ring 2.4s ease-out infinite}
@keyframes mva-ring{from{transform:scale(1);opacity:.9}to{transform:scale(2.6);opacity:0}}
.mva-chain{list-style:none;margin:24px 0 0;padding:0;display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:14px}
.mva-chain li{background:var(--bl-bg);border:1px solid var(--bl-line);border-radius:var(--bl-radius);padding:20px}
.mva-chain li>span{display:inline-grid;place-items:center;width:34px;height:34px;border-radius:10px;background:#fff;border:1px solid var(--bl-line);color:var(--bl-blue-deep);font-weight:700;font-size:.85rem}
.mva-chain strong{display:block;margin:12px 0 6px;font-size:1rem}
.mva-chain p{font-size:.9rem}
.mva-outro{margin-top:18px;font-size:.92rem;max-width:820px}
.mva-funnel{list-style:none;margin:24px 0 0;padding:0;display:grid;gap:8px}
.mva-funnel li{display:grid;grid-template-columns:150px minmax(0,1fr) minmax(0,1.3fr);gap:16px;align-items:center;background:#fff;border:1px solid var(--bl-line);border-radius:var(--bl-radius-sm);padding:12px 18px;margin-inline:calc(var(--i) * 10px)}
.mva-funnel strong{font-size:1.15rem;letter-spacing:-.02em;color:var(--bl-blue-deep);font-variant-numeric:tabular-nums}
.mva-funnel span{color:var(--bl-text-soft);font-size:.92rem}
.mva-funnel code{font:.78rem ui-monospace,SFMono-Regular,Menlo,monospace;color:var(--bl-text-soft);overflow-wrap:anywhere}
.mva-code{margin:0;background:#0d1b33;color:#dbe7f7;border-radius:var(--bl-radius);padding:22px 24px;font:.82rem/1.7 ui-monospace,SFMono-Regular,Menlo,monospace;overflow-x:auto}
.mva-code .k{color:#8fd3f4}
.mva-code .c{color:#7f93b5}
.mva-privacy-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:16px;margin-top:24px}
.mva-privacy-grid article{padding:22px}
.mva-privacy-grid h3{font-size:1.05rem;margin:12px 0 8px}
.mva-privacy-grid p{font-size:.9rem}
.mva-privacy-grid code{font:.82rem ui-monospace,monospace;background:var(--bl-bg);padding:1px 5px;border-radius:5px}
.mva-links{display:flex;flex-wrap:wrap;gap:10px 24px;margin-top:22px;font-weight:600}
.mva-links a{text-decoration:none}
.mva-links a:hover{text-decoration:underline;text-underline-offset:3px}
.mva-acknowledgement{margin-top:20px;background:#fff;border:1px solid var(--bl-line);border-radius:var(--bl-radius);padding:24px 26px}
.mva-acknowledgement h3{font-size:1.1rem}
.mva-acknowledgement p{margin-top:10px;color:var(--bl-text-soft);font-size:.92rem;line-height:1.75;max-width:900px}


/* Responsive */
@media(max-width:1023px){
  .mva-hero-grid{grid-template-columns:1fr;gap:28px}
  .mva-facts{max-width:720px}
  .mva-intro{grid-template-columns:1fr;gap:14px;margin-top:40px}
  .mva-stats{grid-template-columns:repeat(2,minmax(0,1fr))}
  .mva-conclusion-grid{grid-template-columns:1fr;gap:14px}
  .mva-next-layout{grid-template-columns:1fr}
  .mva-next-art{max-width:720px}
  .mva-sources-grid{grid-template-columns:1fr}
  .mva-split{grid-template-columns:1fr;gap:16px}
  .mva-chain{grid-template-columns:repeat(2,minmax(0,1fr))}
  .mva-privacy-grid{grid-template-columns:1fr}
  .mva-track1-context>summary{grid-template-columns:1fr}
  .mva-research-body .bl-section{padding:56px 0}
}
@media(max-width:680px){
  .mva-hero{padding:16px 0 44px}
  .mva-hero h1{font-size:2.2rem}
  .mva-hero-subtitle{font-size:1.05rem}
  .mva-hero-lead{font-size:1rem}
  .mva-hero .bl-actions{display:grid;grid-template-columns:1fr}
  .mva-facts{padding:20px}
  .mva-stats{gap:10px}
  .mva-stats article{padding:14px}
  .mva-stats strong{font-size:1.45rem}
  .mva-question-grid{grid-template-columns:1fr;gap:16px}
  .mva-question-art{margin:0 14px}
  .mva-question-head{padding:12px 14px}
  .mva-question-caption,.mva-question-text{padding-inline:14px}
  .mva-allele-grid{grid-template-columns:1fr}
  .mva-chain{grid-template-columns:1fr}
  .mva-funnel li{grid-template-columns:1fr;gap:4px;margin-inline:0}
  .mva-track1-content{padding:4px 18px 22px}
  .mva-track1-context>summary,.mva-source-list summary,.mva-scope{padding:20px 18px}
  .mva-source-list summary::after{top:18px;right:16px}
  .mva-source-list ol{padding:18px 18px 18px 36px}
  .mva-research-body .bl-section{padding:46px 0}
}
@media(prefers-reduced-motion:reduce){.mva-p-hit-ring{animation:none}}
@media print{.bl-header,.bl-footer{display:none!important}}

/* Track 1 locus helix (labs-dna geometry) inside the dark locus panel. */
.mva-panel .sfl-dna{position:absolute;inset:0;width:100%;height:100%;display:block}
.mva-panel-art{position:relative}
.mva-panel .sfl-dna-b0{fill:#0e2466}.mva-panel .sfl-dna-b1{fill:#132f86}.mva-panel .sfl-dna-b2{fill:#1a3fa6}.mva-panel .sfl-dna-b3{fill:#2352c4}.mva-panel .sfl-dna-b4{fill:#3a72e0}.mva-panel .sfl-dna-b5{fill:#5690f2}.mva-panel .sfl-dna-b6{fill:#76b0fb}.mva-panel .sfl-dna-b7{fill:#9cd3ff}
.mva-panel .sfl-dna-glow{fill:#4aa3ff;fill-opacity:.17}
.mva-panel .sfl-dna-core{fill:#f2fbff;fill-opacity:.8}
.mva-panel .sfl-dna-rungs line{stroke:#a8dcff;stroke-linecap:round}
.mva-panel .sfl-dna-far{fill:#3a74f0;fill-opacity:.12}.mva-panel .sfl-dna-far--wide{fill-opacity:.05}
.mva-panel .sfl-dna-far-drift{animation:mva-dna-drift 16s ease-in-out infinite alternate}
.mva-panel .sfl-dna-twinkle{animation:mva-dna-twinkle 3.2s ease-in-out var(--d,0s) infinite alternate}
@keyframes mva-dna-drift{from{transform:translate(-14px,6px)}to{transform:translate(14px,-6px)}}
@keyframes mva-dna-twinkle{from{opacity:.25}to{opacity:1}}
@media(prefers-reduced-motion:reduce){.mva-panel .sfl-dna *{animation:none!important}}