AI + BIOLOGY + REPRODUCIBLE COMPUTING

NeuroFly

A research sandbox for testing how AI could detect, predict and compensate for functional decline in Drosophila neurodegeneration models.

Current public demo uses a deterministic synthetic model. NF-001 is an animated agent driven by experiment state; it is not a living organism or a biological brain.

NF-001 / LIVE CHAMBER SIMULATED AGENT

neurofly@lab:~$ boot --agent NF-001

✓ model neurofly-synthetic-v0.1 loaded

✓ chamber boundaries active

state: exploring

experiment: early-detection

signal: baseline

SENSOR FIELD

BOUNDARY

runtime active 00:00:00

3research questions

100%reproducible synthetic runs

0clinical claims

APIexperiment-first architecture

EXPERIMENT REGISTRY

Questions before claims

simulation early-detection

Early Neurodegeneration Detection

Can longitudinal behavioral signals reveal a synthetic disease trajectory before a conventional threshold is crossed?

locomotionturning_entropysleep_fragmentationstimulus_latency

simulation prospective-risk

Prospective Progression Prediction

Can an early behavioral window predict later synthetic functional decline?

baseline_deviationfuture_decline_scoretime_to_threshold

simulation adaptive-compensation

AI Adaptive Compensation

Can a closed-loop controller reduce task errors in a synthetic impaired agent without changing the disease model?

task_successpath_efficiencydecision_errorsassistance_cost

LIVE SYNTHETIC SANDBOX

Run a reproducible trajectory

synthetic result

—

AI signal day—

Conventional threshold—

Lead—

AI assistance delta—

RESEARCH ROADMAP

From sandbox to defensible science

Phase 0 — Synthetic validation. Exercise the architecture, provenance, APIs and visualization without pretending the values are biological.
Phase 1 — Public datasets. Train and evaluate behavioral models on published Drosophila tracking datasets with explicit provenance.
Phase 2 — External lab collaboration. Prospectively test early-detection hypotheses in an established neurodegeneration model under appropriate institutional oversight.
Phase 3 — Closed-loop assistance. Evaluate whether adaptive sensory feedback changes task performance, clearly separating compensation from treatment.