References, not copies: every entry links to its original source and keeps where its metadata came from. Reading states organise the library; they are not a judgement of scientific quality.
Kara L. Davis, Elizabeth Fox, Emasenyie Isikwei and 7 moreClinical Cancer Research
PURPOSE: In many cancers, nivolumab in combination with ipilimumab improves response rates compared with either agent alone, but the combination has not been evaluated in childhood cancer. We conducted a phase I/II trial… abstract via OpenAlex
Evidence snapshot note: A Phase I/II Trial of Nivolumab Plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: ADVL1412. Model: Children and young adults with recurrent/refractory solid tumors.. Where: Abstract reproduced by the investigators at Children's Oncology Group; Figure 3A located in indexed primary text. · cited by MVA-IMMUNE-011
Christoph Steurer, Sarah Kerschbaum, Christina Wegrostek and 5 moreMolecular Biotechnology
Abstract The heat shock response (HSR) pathway is a highly conserved rescue mechanism, which protects the cells from harmful insults disturbing the cellular protein homeostasis via expression of chaperones. Furthermore, … abstract via Crossref
Evidence snapshot note: Steurer et al. — HSF1 reporter evaluation. Model: Human HSF-responsive reporter and endogenous target systems. Where: Table 1 and Figure 4: negative arimoclomol response in this system · cited by MVA-ARI-007
Kohei Omachi, Hirofumi Kai, Michel Roberge, Jeffrey H. MineriScience
Alport syndrome, a disease of kidney, ear, and eye, is caused by pathogenic variants in the COL4A3 , COL4A4 , or COL4A5 genes encoding collagen α3α4α5(IV) of basement membranes. Collagen IV chains that are truncated due … abstract via Europe PMC
Evidence snapshot note: Omachi et al. — COL4A5 readthrough reporters. Model: HEK293 COL4A5 cDNA reporters; different gene and context. Where: Figure 6: gentamicin plus mefloquine · cited by MVA-RT-002
Nonsense-mediated mRNA decay (NMD) degrades transcripts with premature stop codons. Given the prevalence of nonsense single nucleotide polymorphisms (SNPs) in the general population, it is urgent to catalog the effects o… abstract via Europe PMC
Evidence snapshot note: Zhao et al. — molecular profiling of NMD modulators. Model: Mouse Neuro-2a; three AS-NMD isoform reporters. Where: Tables S1/S2/S4; Figures 2–5 and 7 · cited by MVA-NMD-003, MVA-AMLEXANOX-010
Markus T. Sainio, Tiina Rasila, Svetlana M. Molchanova and 12 moreFrontiers in Cell and Developmental Biology
Neurofilament light (NFL) is one of the proteins forming multimeric neuron-specific intermediate filaments, neurofilaments, which fill the axonal cytoplasm, establish caliber growth, and provide structural support. Domin… abstract via Crossref
Evidence snapshot note: NEFL motor-neuron negative rescue. Model: Human iPSC-derived NEFL nonsense motor neurons. Where: Figure 6; Treatments · cited by MVA-AMLEXANOX-010
External results are not part of the library. They come live from the public sources named on each card; save one to keep it with its provenance.
Type a query above and search the public sources. Results stay separate from the library until you save them.
BioLab is the biomedical research area of Stackfire Labs: research cases built around open evidence, reproducible reanalyses and an explicit record of what remains unresolved. It organizes evidence and proposes experiments; it does not run patient experiments or recommend treatments.
Two germline BUB1B variants in mosaic variegated aneuploidy raise separate questions: L737* is an RNA and translation question, N1002K a protein stability and function question. The case records reanalyses and evidence audits, an October 24, 2026 robustness audit and a candidate decision matrix. No exact-genotype pharmacological rescue is established; wet-lab validation remains future work.
A shared research library of publications kept as references, not copies. Every entry links to its original source and records which public bibliographic services supplied its metadata and when. Reading states and collections are bibliographic organization, never scientific validation.
The graph connects a case to its variants, processes, evidence records, publications and hypotheses. Solid lines are documented connections; dashed lines are hypotheses under review. A connection says that a source or record links two items: it is not evidence of causation or efficacy. Every view also has a list alternative.
A research trail is an ordered reading of the evidence, step by step. Hypotheses are statements under research with the evidence that informs or limits them; none is marked validated. Evidence gaps name what has not been measured or located. All of them link to existing records and publications instead of copying them.
The auditable record of the MVA reanalyses with their execution records and downloads, and a Protein Structure Explorer of the predicted BUBR1 model. Tools marked Planned are not built yet. Reanalyses of public processed data and predicted structures are not biological experiments.
No. BioLab is research context, not a clinical diagnostic report or a treatment recommendation. Drug candidates are research hypotheses with explicit gates, not proven treatments. Questions about a person’s care belong with their clinical team.